A Pilot Study on Whey Protein Supplementation in Non Alcoholic Fatty Liver Disease

University of Lausanne11 enrolled

Overview

An increase in dietary protein intake has been shown to blunt the increase in intrahepatic fat induced by high fat feeding in healthy individuals. The purpose of this study is to determine if a protein supplementation decreases intrahepatic fat in obese patients with non-alcoholic fatty liver disease.

12 obese patients will be be treated with a dietary whey protein supplementation over 4 weeks. Their intrahepatic fat content, glucose tolerance, and body weight will be evaluated before and after 4 weeks of supplementation.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Non-alcoholic Fatty Liver Disease Obesity

Interventions

ProWHEY 94 CFM, SponserRDIETARY_SUPPLEMENT

3 times 20g per day

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * BMI higher than 35 kg/m2 * age 18-50 years * sex male or female * ASAT/ALAT \> 1.8 Exclusion Criteria: * treatment with hypolemic or antidiabetic agents * blood glucose \> 7 mmol/l * alcohol intake \> 20g/day * creatinin \> 120 umol/l) * contra-indications to Magnetic resonnance imaging

Locations (1)

Centre d'investigations cliniques "cardiomet"/ CHUV

Lausanne, Canton of Vaud, Switzerland

Outcomes

Primary Outcomes

intrahepatic fat

Time frame: before and after 4 weeks of whey protein supplementation

Secondary Outcomes

glucose metabolism

Time frame: 4-hour oral glucose tolerance test with indirect calorimetry

body weight and body fat

Time frame: before and after 4 weeks whey protein supplementation

Data from ClinicalTrials.gov

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