Soft tissue sarcomas represent less than 1% of malignant tumors in adults and sarcomas members represent 60% of them. These rare tumors involve complex multidisciplinary care better in centers having expertise. Loco-regional therapy strategies have evaluated over time for tumors of members leading to propose more often the combination of a large conservative tumor excision with radiotherapy. Results have been demonstrated equivalent to those of an amputation in terms of local control and survival. The local recurrence rate for sarcomas of the members of any kind after surgery with or without radiotherapy in the literature varies from 10 to 30%. The main objective is to achieve a low recurrence rate while maintaining the function. The question remains the possibility of an absence of irradiation in selected cases in a de-escalation therapy order.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
77
50 grays in 25 fractions of 2 Gys or 50.4 grays in 28 fractions of 1.8 grays
absence of radiotherapy
Institut de Cancérologie de l'Ouest - Centre Paul Papin
Angers, France
Institut Bergonié
Bordeaux, France
Centre François Baclesse
Caen, France
Centre Jean Perrin
Clermont-Ferrand, France
Hopital Mondor
Créteil, France
Centre Oscar Lambret
Lille, France
Centre Léon Bérard
Lyon, France
Institut Paoli Calmette
Marseille, France
CHU de la Timone
Marseille, France
Institut du Cancer de Montpellier - Val d'Aurelle
Montpellier, France
...and 8 more locations
Evaluation of local control at 5 years after surgery compared with exclusive post-operative radiotherapy for soft tissue tumors of the members who have surgery with wide excision margins greater than or equal to 10 mm.
Time frame: 2021
Evaluation of the quality of life by questionnaire of quality of life QLCQ30
Time frame: 2021
Evaluation of acute and late complications
Time frame: 2009 to 2021
Overall Survival
Time frame: 2021
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