Pilot Study Evaluating Stress Response and Immune Function in Mechanically Ventilated Patients With Alcohol Use Disorders Treated With Propofol or Midazolam

Inclusion Criteria: * Diagnosis of alcohol use disorders * Need for invasive mechanical ventilation * Need for continuous intravenous infusion of sedative(s) Exclusion Criteria: * Age \< 18 years * Pregnant women * Prisoners * Receiving propofol prior to randomization * Patient experiencing active alcohol withdrawal * Immunosuppression * Shock * Attending physician does not feel patient is candidate to receive either propofol or midazolam * Patient has contraindication(s) to receiving either propofol or midazolam * Inability to enroll patient within 96 hours after initiation of mechanical ventilation * Transfer from another intensive care unit