Anatomic and Visual Function Assessments on Asymptomatic HIV-positive Patients

Federal University of São Paulo90 enrolled

Overview

The purpose of this study is to assess retinal nerve fiber layer thickness and macular thickness measured with optical coherence tomography (OCT) on patients infected by HIV virus without ocular manifestations and to correlate these results with perimetric findings assessed by frequency doubling technology perimetry (FDT).

Study Type

OBSERVATIONAL

Enrollment

Conditions

HIV Infections Acquired Immunodeficiency Syndrome

Interventions

Optical Coherence Tomography (OCT)DEVICE

Macular and retinal nerve fiber layer OCT (Stratus OCT, Carl Zeiss Meditec, Dublin, CA) will be performed both in patients and controls

Frequency Doubling Technology (FDT) perimeterDEVICE

24-2 FDT Threshold (Humphrey Matrix, Carl Zeiss Meditec, Dublin CA; Welch-Allyn, Skaneateles, NY) will be performed both in patients and controls.

Eligibility

Sex: ALLMin age: 21 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of AIDS * Best-corrected visual acuity 20/25 or better * Refractive error of 0±5.0 diopters and astigmatism of 0±3.0 diopters * Normal intraocular pressure (≤21mmHg) Exclusion Criteria: * Cataract or any visible media opacity * HIV-related infectious retinopathy * Risk factors for the development of glaucoma

Locations (1)

Federal University of São Paulo (UNIFESP/EPM)

São Paulo, São Paulo, Brazil

Data from ClinicalTrials.gov

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