Fosfomycin Plus Imipenem for Treatment of Infective Endocarditis

Inclusion Criteria: * Suspected methicillin-resistant staphyloccocus aureus infective endocarditis on a native valve, prosthetic valve or pacemakers´s electrode or defibrillators with definitive or probable diagnosis by the modified Duke criteria (Li J, et al. Clin Infect Dis. 2000). * Patients over 18 years. Exclusion Criteria: * Patients who did not sign informed consent. * Patients with active consumption intravenous drug. * Patients with emergent surgery criteria (\<72 hours). * Patients or cardiogenic shock. * Patients with antibiotic active against MRSA over 72 hours or they may need another antibiotic active against MRSA than those in the study. * Patients with chronic renal failure on hemodialysis who received empirical treatment with vancomycin as a single dose and have a valley ≥ 15 mcg / mL on the third day. * Patients with MRSA strains resistant to fosfomycin (MIC\> 64 mg / L) (\<10%) or vancomycin (MIC\> 2 mg / L) or with an MIC to vancomycin of 2 mg / L. * Patients with any formal contraindication to be treated with study drugs * Patients treated with any investigational drug within 30 days prior to entering the study.