Endoscopic Evaluation of Upper Gastrointestinal (GI) Mucosal Damage Induced by PL-2200 Versus Aspirin in Healthy Volunteers

Inclusion Criteria: * Subject is ≥50 to ≤75 years of age. * Subject is healthy. * Subject has a BMI between 20 and 32 * If female and of child bearing potential, subject has a negative pregnancy test and is not nursing. Exclusion Criteria: * Subject has abnormal screening/baseline laboratory parameters or endoscopic observations deemed clinically significant by the Investigator. * Subject has an active Helicobacter pylori infection. * Subject has a prior GI ulcer, bleeding, obstruction or perforation. * Subject has taken aspirin or any aspirin containing product within the last 4 weeks, or a non-aspirin NSAID product within 2 weeks. * Subject has taken any of the following medications within 2 weeks prior to enrollment: Any anti-platelet agents, anti-coagulants or selective serotonin reuptake inhibitors. * Subject has used an investigational agent within the past 30 days. * Subject has hypersensitivity or contraindications to aspirin, ibuprofen, or other NSAID.