This study is designed to evaluate the additional efficacy and safety of olmesartan medoxomil/hydrochlorothiazide in the treatment of Chinese patients with mild to moderate essential hypertension, who fail to attain the blood pressure goals with olmesartan medoxomil monotherapy
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
304
olmesartan medoxomil 20mg oral tablets, once daily for 4 weeks then olmesartan medoxomil 20mg oral tablets + hydrochlorothiazide 12.5 mg oral tablets, once daily for up to 8 weeks
olmesartan medoxomil 20mg oral tablets, once daily for 4 weeks then olmesartan medoxomil 40mg oral tablets, once daily for up to 8 weeks
Unnamed facility
Beijing, China
Unnamed facility
Chengdu, China
Unnamed facility
Chongqing, China
Unnamed facility
Guangzhou, China
Unnamed facility
Mean change of trough seated diastolic blood pressure from baseline to Week 12 between the two treatment groups.
Time frame: Baseline to12 weeks
The mean change of trough seated systolic blood pressure from Week 5 to Week 12 between the two treatment groups
Time frame: 8 weeks (week 5 to week 12)
The mean change of trough seated diastolic blood pressure and seated systolic blood pressure from Week 5 to Week 9 between the two treatment groups
Time frame: 5 weeks (Week 5 to week 9)
The response rate in the two treatment groups from baseline to Week 9
Time frame: Baseline to 9 weeks
The response rate in the two treatment groups from baseline to Week 12
Time frame: Baseline to 12 weeks
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Hangzhou, China
Unnamed facility
Nanjing, China
Unnamed facility
Shanghai, China
Unnamed facility
Wuhan, China