Effects of Hydroxychloroquine on Oral Complaints of Sjögren Patients

Ege University30 enrolled

Overview

Chronic inflammation that comprises the exocrine glands' function leads to xerophthalmia and xerostomia in Sjögren's syndrome. The oral consequences range widely and they are related to decreased salivary output. Hydroxychloroquine may inhibit cholinesterase activity in salivary glands via interference with antigen processing mechanism, and thus, the investigators' hypothesis was that salivary gland function may be improved if treated with hydroxychloroquine. The effects of hydroxychloroquine on the salivary flow rate, subjective and objective parameters of the patients were also assessed.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Sjögren's Syndrome Xerostomia

Interventions

HydroxychloroquineDRUG

Eligibility

Sex: FEMALE

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who were recently diagnosed with primary SS according to American-European criteria and who were scheduled for HCQ treatment in Ege University Faculty of Medicine, Department of Rheumatology Exclusion Criteria: * Sjögren patients consuming alcohol or tobacco

Locations (1)

Ege University School of Dentistry

Izmir, Bornova, Turkey (Türkiye)

Outcomes

Primary Outcomes

Salivary flow rate, objective and subjective clinical oral complaints

Time frame: 2005 Jan-2009 Jan

Data from ClinicalTrials.gov

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