Safety and Tolerability Study of Cogane™ in Healthy Volunteers and Parkinson's Disease Patients

Key Inclusion Criteria (Healthy Volunteers): * Male \& Female healthy volunteers aged between 40 and 80 years at the time of informed consent * Females of non-childbearing potential * General Good Health Key Exclusion Criteria (Healthy Volunteers): * No clinically significant and relevant medical history * Smoked within the 3 months prior to screening * Use of prescription or non-prescription systemic or topical medication (including herbal remedies) within 14 days of the first dose administration Key Inclusion Criteria (Parkinson's disease patients): * Male \& Female Parkinson's disease patients aged between 40 and 80 years at the time of informed consent * Must have a diagnosis of idiopathic Parkinson's disease according to the UK Parkinson's Disease Society Brain Bank criteria * Subjects who are taking Parkinson's disease treatments should be on a stable regimen for at least 4 weeks prior to screening Key Exclusion Criteria (Parkinson's disease patients): * Diagnosis of dementia * Parkinson's disease of a known genetic cause * History of surgical intervention for Parkinson's disease