The purpose of this study is to determine whether the iTBS is an effective treatment of the negative symptoms of schizophrenia.
This study will evaluate whether the intermittent Theta Burst Stimulation (iTBS), a new high frequency TMS protocol is efficient in the treatment of the Negative Symptoms of schizophrenia. Neuroimaging studies demonstrate that hypoactivity in the left dorsolateral prefrontal cortex (LDLPFC) was associated with negative symptoms. The investigators hypothesize that iTBS applied to LDLPFC will improve negative symptoms and will improve activity of the LDLPFC measured with Magnetic Resonance Spectroscopy (MRS).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
22
Intermittent Theta Burst Stimulation (iTBS) over Left dorsolateral prefrontal cortex. 80% MT, 20 sessions of 6 minutes, 2 per day
iTBS placebo (placebo coil)
Hopital Le vinatier
Bron, France
Scale for the Assessment of Negative Symptoms (SANS)
Time frame: before, after 2 weeks of treatment, and 3 times follow-up (1, 3 and 6 months)
Neurochemical impact of treatment measured by 1H-MRS, DTI and resting MRI
Time frame: 3 times, before treatment, immediatly after treatment and a last evaluation 3 months after
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