Choosing the Right Pacing Mode in Heart Failure - The CHOICE Trial

University of Dundee22 enrolled

Overview

The aim of the study is to see if biventricular pacemakers offer any advantage over conventional pacemakers in patients with heart failure who require pacemakers. The endpoints will be the 6 minute walking distance along with markers of cardiovascular function. The investigators' hypothesis is that biventricular pacing is preferable to conventional pacing in these heart failure patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Heart Failure

Interventions

Bi Ventricular PacingDEVICE

Right Ventricular PacingDEVICE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Left ventricular systolic dysfunction. 2. Atrio-ventricular node disease. 3. Anticipated to be more than 40% paced, (including patients in permanent atrial fibrillation). 4. Ability to walk independently (walking aid permitted). Exclusion Criteria: 1. Patients meeting criteria for CRT by current guidelines will be excluded. 2. Life expectancy less than12 months. 3. Inability to walk independently. 4. Patients not likely to be compliant with follow-up. 5. Bradyarrhythmia due with sino-atrial disease only.

Locations (1)

Ninewells Hospital & Medical School

Dundee, UK, United Kingdom

Outcomes

Primary Outcomes

6 minute hall walk test

Time frame: Baseline, 3, 6, 9 and 12 months

Secondary Outcomes

Endothelial Function

Time frame: Baseline, 3, 6, 9 and 12 months

Cardiac Output

Time frame: Baseline, 3, 6, 9 and 12 months

Data from ClinicalTrials.gov

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