Study Assessing Immunogenicity and Safety of IC43 In Intensive Care Patients

Inclusion Criteria: * Male or female patients aged between 18 and 80 years * Patients admitted to an ICU with a need for mechanical ventilation for more than 48 hours at visit 0 * At high risk for acquiring infection against P. aeruginosa at visit 0. * Patients who, as determined by the investigator, have a high probability of survival for at least 48 hours. * In females, either childbearing potential terminated by surgery or 1 year post menopausal, or a negative pregnancy test and the willingness of practicing a reliable methods of contraception * Written informed consent or waiver according to the national regulations Exclusion Criteria: * Known use of any other investigational or non-registered drug within 30 days prior to IC43 vaccination at Visit 0 * Low severity of illness defined by an acute physiology score \< 8 at visit 0 * Patients \< 6 months post organ transplantation * Severe thrombocytopenia or other coagulopathy which in the opinion of the investigator makes the patient unsuitable for intramuscular injection * Pregnancy, lactation * Persons who have been committed involuntarily to an institution, e.g. mental health facility or prison, will not participate in the study