Evaluation of Different Continuous Positive Airway Pressure (CPAP) Systems in Patients With Acute Respiratory Failure

Policlinico Hospital30 enrolled

Overview

The aim of this study is to evaluate the performance, the tolerability and the efficacy on gas-exchange of different CPAP (Continuous Positive Airway Pressure) systems.

Three CPAP systems are studied for each patient at the same level of PEEP: 1) continuous high-flow CPAP with fixed value PEEP valve; 2) continuous high-flow CPAP with Boussignac PEEP valve; 3) demand flow CPAP, supplied by a ventilator.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Acute Respiratory Failure

Interventions

CPAP systemPROCEDURE

Evaluating the effects of different CPAP systems on respiratory mechanics, respiratory effort and gas-exchange CPAP systems: Continuous high-flow CPAP with fixed value PEEP valve Continuous high-flow CPAP with Boussignac valve Demand flow CPAP supplied by ventilator

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Intubated-tracheostomized subjects receiving CPAP during the weaning from invasive mechanical ventilation Exclusion Criteria: * Hemodynamic instability * Barotrauma * Severe myopathy

Locations (1)

Policlinico Hospital

Milan, Italy

Outcomes

Primary Outcomes

Respiratory mechanics, work of breathing, end-expiratory lung volume (EELV) and gas exchange

Time frame: 30 minutes

Secondary Outcomes

Comfort of breathing

Time frame: 30 minutes

Data from ClinicalTrials.gov

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