Effect of Remote Ischemic Preconditioning on Cognitive Function After Cardiac Surgery

Patrick Meybohm180 enrolled

Overview

The purpose of this study is to evaluate the effects of Remote Ischemic Preconditioning on cognitive function in patients undergoing cardiac surgery compared to control intervention.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

180

Conditions

Cardiac Surgery

Interventions

Remote Ischemic PreconditioningPROCEDURE

RIPC will be induced during anesthesia by four 5-min cycles of upper limb ischemia and 5-min reperfusion using a blood-pressure cuff inflated to 200 mmHg (at least a pressure 15 mm Hg greater than the systolic arterial pressure measured via the arterial line).

ControlOTHER

Sham intervention with four 5-min cycles of inflation of the blood pressure cuff at 20 mmHg and 5 min deflation without any upper leg ischaemia.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient undergoing heart surgery on cardiopulmonary bypass Exclusion Criteria: * Emergency cases * Myocardial infarction up to 7 days prior to enrollment * Stroke up to 2 months prior to enrollment * Ejection fraction less than 30% * Previous psychiatric and neurological illness * Inability to give informed consent

Locations (1)

University Hospital Schleswig-Holstein

Kiel, Germany

Outcomes

Primary Outcomes

The primary outcome measure is postoperative neurocognitive dysfunction.

Time frame: Preoperative, 1 week and 3 months after surgery

Secondary Outcomes

New onset of atrial fibrillation, myocardial and kidney injury, cardiac function (previous NCT00882622 study).

Time frame: Within 24-48 hours after surgery

Data from ClinicalTrials.gov

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