Prospective Studies of the Pathogenesis of Schizophrenia

University of North Carolina, Chapel Hill598 enrolled

Overview

The purpose of this study is to use structural and functional magnetic resonance imaging (MRI) to study children at high risk for schizophrenia. It is hypothesized that children at high risk for schizophrenia will have abnormalities of brain development, especially of the cerebral cortex. The study will also describe normal brain development in children from birth to age 6 years

We are currently following enrolled children at 4 and 6 years of age. We are obtaining structural MRIs and rsfMRIs. In addition, we are assessing cognitive function and behavior with Stanford-Binet, BRIEF and BASC.

Study Type

OBSERVATIONAL

Enrollment

598

Conditions

Schizophrenia

Eligibility

Sex: ALLMax age: 6 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * control, offspring of mother with schizophrenia or bipolar illness; child with MVM Exclusion Criteria: * major neurological or medical illness

Locations (1)

UNC Department of Psychiatry

Chapel Hill, North Carolina, United States

Outcomes

Primary Outcomes

magnetic resonance images (structural and functional)

Time frame: birth, ages 1, 2 , 4 and 6 years

Secondary Outcomes

Cognitive development

Time frame: 0,1,2,4 and 6 years

Data from ClinicalTrials.gov

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