Early Chemotherapy Intensification in Interim-Positron Emission Tomography (PET) Positive Hodgkin Lymphoma

Ospedale Santa Croce-Carle Cuneo160 enrolled

Overview

Early interim-PET after two courses of chemotherapy is a powerful outcome predictor in advanced-stage Hodgkin Lymphoma (HL) patients treated with adriamycin (doxorubicin), bleomycin, vinblastine and dacarbazine (ABVD). Two-year Progression Free Survival of PET-2 positive patients is only 12%, but the optimal treatment for this patient subset is still unknown. From January 2006 GITIL (Gruppo Italiano Terapie Innovative nei Linfomi) suggested an early intensification of chemotherapy with BEACOPP \[Bleomycin, Etoposide, Adriamycin (doxorubicin), Cyclophosphamide, Oncovin (vincristine), Procarbazine, and Prednisone\](4 escalated + 4 baseline cycles) for all the HL patients with a positive PET-2 after 2 ABVD courses. The investigators retrospectively recorded and analyzed these data in order to evaluate if this strategy could be of benefit for this subset of patients.

Study Type

OBSERVATIONAL

Enrollment

160

Conditions

Hodgkin Lymphoma

Eligibility

Sex: ALLMin age: 16 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with advanced Hodgkin's lymphoma according to the World Health Organization classification * Age 16-80 * Not previously treated * Stage IIB to IVB or stage IIA with adverse prognostic factors (more than 3 nodal sites, ESR \> 50 mm, bulky lesion) * Written informed consent Exclusion Criteria: * Patients aged more than 80 * Concomitant or previously treated neoplastic disorder less than 5 years before the diagnosis of Hodgkin's lymphoma * Psychiatric disorders * Uncontrolled infectious disease * Impaired cardiac (EF \< 50%) or renal (creatinine clearance \< 60 ml/m)function * Pregnancy and lactation * Uncompensated diabetes mellitus and fasting glucose levels over 200 mg/dl

Outcomes

Primary Outcomes

Progression Free Survival

Time frame: 2 years

Secondary Outcomes

Incidence of progression/relapse

Time frame: 2 years

Interim PET positive and negative predictive value

Time frame: 2 years

Early Chemotherapy Intensification in Interim-Positron Emission Tomography (PET) Positive Hodgkin Lymphoma

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes