Short-term Metabolic Effects of Mirtazapine in Healthy Subjects

Inclusion Criteria: * Male sex * Age 20-25 years * Somatically and mentally healthy * Normal body weight (body mass index (BMI)18.5-25) Exclusion Criteria: * Smoking within the last 6 months * Medication within last 6 months * Current or former psychiatric illness * Positive family history (first grade relatives) for metabolic diseases * Alcohol abuse * Current or former illicit drug abuse * Current or former drug abuse * Known intolerance to, or former prescription of study medication * Participation in other clinical trials at the same time or participation in clinical trials associated with administration of a drug within the last 6 months * Homelessness * Shift work within last 12 months * Known hypersensitivity to mirtazapine or other components of the drug given * Known epilepsy; glaucoma; liver, kidney, or heart disease; urinary dysfunction; hypotonia; diabetes or any other metabolic disease * Known hematologic disease, especially agranulocytosis or leukopenia * Blood donation within last 6 months prior to the begin of the study * Hemoglobin below 13.5 mg/dL