Study of MB07811 in Subjects With Hypercholesterolemia

Inclusion Criteria: * Body mass index (BMI) 18.50 - 40 kg/m2 inclusive at screening; * Fasting serum LDL-C ≥145 mg/dL at both Q2 and Q3 visits; * Fasting mean serum LDL-C \<220 mg/dL from Q2 and Q3; Exclusion Criteria: * History of clinically significant cardiovascular disease * Uncontrolled hypertension * Significant sinus bradycardia defined as \<40 beats per minute (bpm); * Personal or family history of clinically significant unexplained syncope, near-syncope or unexplained sudden death or QT syndrome; * Holter monitor report demonstrating any abnormality that is clinically significant, including but not limited to PVC frequency \> 1 per minute, any alert criteria or any other condition that requires further evaluation; * History of clinical significant arrhythmia; * Resting 12-lead ECG showing QTc \>450 msec or \<360 msec (males or females), any tachyarrhythmia or morphology change, or any other clinically significant abnormality; * Any other cardiovascular event requiring hospitalization; * History or presence of thyroid disorder or other metabolic/endocrine disorder that affects lipids or glucose; Exceptions: polycystic ovarian syndrome (PCOS) and impaired glucose tolerance (IGT) are allowed. * Liver disease, gallbladder disease, Gilbert's syndrome, biopsy-proven nonalcoholic steatohepatitis (NASH), positive serology for hepatitis B surface antigen (HBsAg) or hepatitis C antibodies; Exceptions: gallbladder disease treated with cholecystectomy * History of human immunodeficiency virus (HIV); * Subjects with a prior history of malignancy in past 5 years;Exceptions: Subjects with previous history of basal or squamous cell carcinoma of the skin, or cervical cancer in situ are allowed if successfully treated; * History of myopathy, including any history of statin-induced myopathy; * History of intolerance to statins (e.g., myalgias, elevated liver tests); * History of clinically significant psychiatric disorders, including but not limited to bipolar disorder, major depressive disorder, psychosis; * Renal dysfunction; * Alcohol and/or drug abuse within 12 months prior to screening;