Taxotere/Prednisone Plus Sunitinib in Chemotherapy-Naïve, Hormone Refractory Prostate Cancer Patients

Inclusion Criteria * Subjects must have a histological diagnosis of adenocarcinoma of the prostate * Age ≥ 18 * Subjects must have metastatic prostate cancer deemed to be unresponsive or refractory to hormone therapy by one or more of the following (despite androgen deprivation and anti-androgen withdrawal when applicable) check all that apply. * Subjects may have received prior surgery. However, at least 21 days must have elapsed since completion of surgery and Subject must have recovered from all side effects. * Subjects must have adequate hepatic function as defined by: * a serum bilirubin ≤1.5 x the institutional upper limit of normal (IULN), * Serum glutamic-oxaloacetic transaminase (SGOT) or serum glutamic-pyruvic transaminase (SGPT) ≤2.5 x the institutional upper limit of normal obtained within 14 days prior to start of therapy * Subjects must have 2 pre-study PSA \> 2ng/ml at least 1 week apart within 28 days prior to start of therapy * Subjects must have been surgically or medically castrated. If method of castration is luteinizing hormone-releasing hormone (LHRH) agonist (leuprolide or goserelin), then the Subject should be willing to continue the use of LHRH agonists. Castration using LHRH agonist should not be interrupted and subjects who have stopped treatment should be willing to restart. * Subjects must not take vitamins, herbs, or micronutrient supplement within 28 days prior to start of therapy. * Prior external beam radiation therapy (to less than 30% of the bone marrow only) is allowed. This includes prior use of samarium, but subjects can not have received prior strontium. At least 28 days must have elapsed since the completion of radiation therapy and the Subject must have recovered from side effects. Soft tissue disease which has been radiated in the prior 2 months is not assessable as measurable disease. * Subjects with a history of myocardial infarction are not eligible. Subjects must have a baseline EKG to rule out underlying cardiac disease within 42 days prior to registration. Subjects with a history of cardiac disease, specifically congestive heart failure (CHF) are ineligible unless their disease is well-controlled. Subjects with history of cardiovascular accident (CVA) or atrial fibrillation are ineligible. * Subjects with a history of brain metastases or who currently have treated or untreated brain metastases are not eligible. Subjects with clinical evidence of brain metastases must have a brain CT or MRI negative for metastatic disease within 56 days prior to registration. \*Liver function tests should be evaluated prior to each treatment. * Subjects must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-2. * Subjects must have an adequate renal function as defined by: * a serum creatinine ≤1.5 x the institutional upper limit of normal obtained within 14 days prior to start of therapy and a urine protein: creatinine (UPC) ratio of ≤ 1.0. * Subjects must have the following hematological criteria (minimal values): * Absolute neutrophil count ≥ 1,500/mm³ * Hemoglobin of ≥ 8.0gm/dL, * White blood cell count ≥ 2500, * Platelets ≥ 75,000/mm³ * Subjects must be able to take oral medications Exclusion Criteria * Subjects must not have received chemotherapy, biologic therapy or any other investigational drug for any reason within 28 days prior to start of therapy and must have recovered from toxicities of prior therapy to grade 1 or less with the exception of alopecia. * Subjects may not have ongoing problems with bowel obstruction or short bowel syndrome characterized by grade 2 or greater diarrhea or malabsorptive disorders. * Men of child bearing potential must be willing to consent to using effective contraception while on treatment and for at least 3 months thereafter. * Subjects with a history of severe hypersensitivity reaction to docetaxel or other drugs formulated with polysorbate 80 will be excluded * Subjects should not have psychological, familial, sociological, or geographical conditions that do not permit medical follow-up or compliance with the study protocol. * Subjects should not have any medical life-threatening complications of their malignancies * Subjects should not have a known severe and/or uncontrolled concurrent medical disease (e.g., uncontrolled diabetes, uncontrolled chronic renal or liver disease, active uncontrolled infection, or HIV). * Subjects should not have current, recent (within 4 weeks of the first infusion of this study), or planned participation in an experimental drug study. * Baseline blood pressure of \< or equal to 150/100 mmHg. Subjects with a blood pressure reading above this level should be initiated on anti-hypertensive therapy and may be considered for protocol treatment when their blood pressure is adequately controlled. * Subjects with New York Heart Association (NYHA) Grade II or greater congestive heart failure are not eligible. Subjects must have a baseline multiple gated acquisition scan (MUGA) or Echocardiogram with a calculated ejection fraction \> or equal to 50%. * Subjects with clinically significant peripheral vascular disease are not eligible. * Subjects with evidence of bleeding diathesis or coagulopathy are not eligible. * Subjects with central nervous system or brain metastases are not eligible. * Subjects who had major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to Day 0, anticipation of need for major surgical procedure during the course of the study are not eligible. * Subjects with minor surgical procedures, fine needle aspirations or core biopsies within 7 days prior to Day 0 are not eligible. * Subjects with history of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess are not eligible. * Subjects with serious, non-healing wound, ulcer, or bone fracture are not eligible. * Subjects who are diagnosed of any other malignancy except non-melanomatous skin cancer in the past 5 years are not eligible. * Subjects receiving anticoagulation therapy (e.g. Coumadin) prior to registration are not eligible. Subjects are permitted to have prior Coumadin for prophylaxis against agents that might produce blood clots. Subjects with low dose Aspirin (86mg) are acceptable. * Subjects with active thrombophlebitis or hypercoagulability are not eligible. Subjects with known history of pulmonary embolus are not eligible. * All Subjects must be informed and must sign and give written informed consent in accordance with institutional and federal guidelines. Subjects who are unable to comply with study and/or follow-up procedures are not eligible.