Impact of the Severity of Pediatric Psoriasis on Childhood Body Mass Index

Northwestern University409 enrolled

Overview

The object of this research study is to examine these associations in children as very little is known about psoriasis and cardiovascular risk factors in the pediatric population.

Several environmental factors and comorbid conditions have been found to be associated with psoriasis in adults, including obesity, depression, smoking, and other cardiovascular risk factors such as high blood pressure. The object of this research study is to examine these associations in children as very little is known about psoriasis and cardiovascular risk factors in the pediatric population. This is a multi-center study with a planned total enrollment of about 200 subjects ages 2-17 years old with psoriasis and 100 aged-match controls. Patient and family history will be recorded. All subjects will undergo standard height, weight, blood pressure, and waist circumference (WC). For the obese and overweight subjects we will also obtain their growth charts to attempt to correlate weight gain with psoriasis onset and progression. All data will be compiled and then statistically analyzed.

Study Type

OBSERVATIONAL

Enrollment

409

Conditions

Psoriasis Atopic Dermatitis

Interventions

Blood pressureOTHER

Blood pressure will be measured once while patient is seated

HeightOTHER

Height will be measured in centimeters at the time of enrollment

WeightOTHER

Weight will be measured in kilograms at enrollment

Eligibility

Sex: ALLMin age: 5 YearsMax age: 17 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Subjects must be between the ages of 5 and 17 years at the time of enrollment. * Subjects of either sex. * Subjects who have had psoriatic plaques for more than 6 months. * Subjects and guardians of minors must sign the approved IRB consent form(s) prior to initiation of the study protocol. * Subjects enrolled as "non-inflammatory" normal controls will carry a common non- systemic skin condition, such as acne, nevi, warts and molluscum as their main diagnosis. * Subjects enrolled as "inflammatory" normal controls will carry a diagnosis of moderate to severe atopic dermatitis. Exclusion Criteria: * Subjects who are unable to give informed consent or assent. * Subjects who have had psoriasis for less than 6 months. * Subjects whose condition is deemed unsafe or incapable by the study investigator for study participation.

Locations (14)

University of California, San Diego

San Diego, California, United States

University of California, San Francisco

San Francisco, California, United States

Stanford University School of Medicine

Stanford, California, United States

Outcomes

Primary Outcomes

BMI

Time frame: 07/2010

Secondary Outcomes

Blood Pressure

Time frame: 07/2010

Waist circumference

Time frame: 07/2010

Data from ClinicalTrials.gov

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