Ibuprofen and Opioid (Morphine or Diamorphine) for Acute Pain in Sickle Cell Disease - Sickle With Ibuprofen & Morphine

Inclusion Criteria: * Adult patients with SCD of any phenotype Exclusion Criteria: * Patient has a history of allergic reaction to either diamorphine/morphine or ibuprofen * Patient has contraindications to diamorphine/morphine or ibuprofen, e.g. peptic ulcer disease, non-steroidal anti-inflammatory drug (NSAID)-induced asthma * Patient in a drug dependency programme * Patient is on renal dialysis * Stroke within the last 6 weeks * Platelet count less than 50 x 10\^9/l * Patient is pregnant or breastfeeding * Doctor unwilling to randomise the patient for other reasons * Previous participation in the trial * Patient receiving drug treatment with which opioids or NSAIDs are likely to interact significantly * Stage 1 - 5 chronic kidney disease (ref Appendix 2), including urine protein: creatinine ratio of \>50 (Because the ibuprofen dose is substantial it is felt that precautions should be taken to exclude those who have any signs of chronic kidney disease. One of the signs of kidney disease is "persistent proteinuria". Therefore, the patient who intermittently has proteinuria(which could be due to other reasons) could still participate.) * Oxygen saturation by pulse oximetry \<94% * Participation in another clinical trial within the last month