This study is being conducted to assess any potential differences in the absorption and excretion between two lanthanum carbonate formulations. This study is also being done to assess the safety and tolerability of the two lanthanum carbonate formulations.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
72
3x's per day for 3 days, 1 dose in the am for day 4. (A single dose equals 1000mg of lanthanum carbonate granule formulation. Dose is administered immediately after each meal.)
3x's per day for 3 days, 1 dose on day 4. (A single dose equals a 1000mg tablet of lanthanum carbonate. Dose is administered immediately after each meal.)
West Coast Clinical Trials, LLC
Cypress, California, United States
Urinary Phosphate Excretion 3-Day Average
Time frame: Continuous collection over 3 days
Urinary Phosphate Excretion on Day 4
Time frame: Continuous collection on Day 4
Area Under the Steady-state Plasma Concentration-time Curve (AUC) of Lanthanum Carbonate
Time frame: 3, 4, 5, 6, 8, 12, 18, 24, 36 and 48 hours post-dose on Day 4
Maximum Plasma Concentration (Cmax) of Lanthanum Carbonate
Time frame: 3, 4, 5, 6, 8, 12, 18, 24, 36 and 48 hours post-dose on Day 4
Time of Maximum Plasma Concentration (Tmax) of Lanthanum Carbonate
Time frame: 3, 4, 5, 6, 8, 12, 18, 24, 36 and 48 hours post-dose on Day 4
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