The Effect of Erythropoietin at the Time of Reperfusion in Acute Myocardial Infarction

Seoul National University Bundang Hospital58 enrolled

Overview

The purpose of this study is to investigate the effect of intravenous human recombinant erythropoietin on the reperfusion injury at primary percutaneous coronary intervention in patients with acute myocardial infarction.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Acute Myocardial Infarction

Interventions

human recombinant erythropoietinDRUG

intravenous bolus injection of EPO (50unit/kg)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Acute myocardial infarction \<12hr * Age \>18yrs * First myocardial infarction * culprit lesion : proximal to mid left anterior descending artery * Baseline coronary flow : TIMI Grade 0\~1 Exclusion Criteria: * Patients with previous myocardial infarction * History of thrombotic complication * History of cerebral infarction * Uncontrolled hypertension * Increased hemoglobin level \>17g/dL * Patients with mechanical valve * Cardiogenic shock

Locations (1)

Seoul National University Bundang Hospital

Seongnam, South Korea

Outcomes

Primary Outcomes

Creatinine kinase (CK), creatinine kinase-MB (CK-MB)

Time frame: 4hr, 8hr, 12hr, 24hr, 48hr, 72hr

Secondary Outcomes

Infarct size assessed by cardiac MRI

Time frame: day 4

Data from ClinicalTrials.gov

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