Use of the Contura™ Catheter to Deliver Accelerated Partial Breast Irradiation to "Low-risk" Breast Cancer Patients

Inclusion Criteria: * Able and willing to sign informed consent * Age 50 or older at diagnosis * Life expectancy greater than 10 years (excluding diagnosis of breast cancer) * Surgical treatment of the breast must have been lumpectomy. The margins of the resected specimen must be histologically free of tumor (negative surgical margins per NSABP criteria) * On histologic examination, the tumor must be DCIS and/or invasive breast carcinoma * For patients with invasive breast cancer, an axillary staging procedure must be performed \[either sentinel node biopsy or axillary dissection (with a minimum of 6 axillary nodes removed), and the axillary node(s) must be pathologically negative\] * The T stage must be Tis, T1, or T2. If T2, the tumor must be less than or equal to 3.0 cm in maximum diameter * Estrogen receptor positive tumor Exclusion Criteria: * Age \< 50 at diagnosis (regardless of histology) * Pregnant or breast-feeding * Active collagen vascular disease * Paget's disease of the breast * Prior history of DCIS or invasive breast cancer * Prior breast or thoracic radiation therapy for any condition * Multicentric carcinoma (DCIS or invasive) * Synchronous bilateral invasive or non-invasive breast cancer * Surgical margins that cannot be microscopically assessed or that are positive * Positive axillary node(s) * T stage of T2 with the tumor \> 3 cm in maximum diameter or a T stage of T3 or T4 * Estrogen receptor negative tumor