XIAP Antisense AEG35156 in Combination With Sorafenib in Patients With Advanced Hepatocellular Carcinoma (HCC)

Inclusion Criteria: * HCC diagnosed by: * Histology, or * AASLD Criteria in which the diagnosis is made clinically in a patient with a known hepatitis B or cirrhosis of other etiology has a liver mass of \> 2cm with typical features of HCC (i.e., hypervascular with washout in the portal/venous phase) on a dynamic imaging study (contrast CT / USG / MRI) or alternatively if the AFP is \>200 ng/ml. * The tumor is not suitable for curative treatment (resection / transplant / local ablative therapies) or the patient is medically inoperable or refuses such treatment. * At least one measurable lesion according to RECIST criteria. * Age \> 18 years. * Life expectancy of greater than 12 weeks. * ECOG performance status ≤ 2 (please refer to Appendix 1). * Child-Pugh score A or B (please refer to Appendix 2). * Adequate organ functions defined as: * ANC ≥ 1.5 x 109/L * Platelet count ≥ 75 x 109/L * Creatinine ≤ 1.5 x ULN * ALT or AST \< 2.5 x ULN * Total bilirubin \< 50 μmol/L * INR \<1.7 * No encephalopathy clinically * Normal ECG * For women of child-producing potential, the use of effective contraceptive methods during the study. * Prior local therapy to tumor (e.g. surgery, RFA, PEI, chemo-embolization, radiotherapy) is allowed provided that there is a target lesion not subjected to local therapy and/or disease progression has been documented in the target lesion subjected to local therapy. The treatment must be completed at least 4 weeks and patient has recovered from all the acute toxicities of that treatment. * For patients with hepatitis B, the patient must receive antiviral therapy prior to or with registration. Exclusion Criteria: * Child-Pugh score C. * Patients who have had prior systemic chemotherapy. * Patients who have had any other cancer related therapy including radiotherapy within 4 weeks prior to entering the study. * Patients receiving any other investigational agents concurrently. * Patients with known brain metastases should be excluded from this clinical trial because of their poor prognosis and because they often develop progressive neurologic dysfunction that would confound the evaluation of neurologic and other adverse events. * Patients who have peripheral neuropathy. * Uncontrolled intercurrent disease such as, but not limited to, ongoing or active infection or psychiatric illness/social situations that would limit compliance with study requirements. * Known bleeding diathesis. * Pregnant or nursing women. NOTE: Women of child-bearing potential must agree to use adequate contraception (sterile or surgically sterile; hormonal or barrier method of birth control; or abstinence) prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately. * Men who are unwilling to use acceptable forms of birth control when engaging in sexual contact with women of child bearing potential. * Active, uncontrolled bacterial, viral, or fungal infections, requiring systemic therapy. * Serious nonmalignant disease that could compromise protocol objectives in the opinion of the investigator and/or the sponsor. * Patients who are currently receiving any other investigational agent. Subjects who have used a previous antisense oligonucleotide in the last 90 days will be excluded. * Unwillingness or inability to comply with procedures required in this protocol.