The Effects of Preconditioning on Intramuscular High-Energy Phosphate Levels During Ischemia

Inclusion Criteria: * Men aged between 18 and 45 years * Nonsmoker for more than 3 months * Body mass index between 18 and 25 kg/m2 * Normal findings in medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant Exclusion Criteria: * Regular use of medication, abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study * Evidence of hypertension, pathologic hyperglycemia, hyperlipidemia * Treatment in the previous 3 weeks with any drug including over-the-counter drugs * Symptoms of a clinically relevant illness in the 2 weeks before the first study day * Blood donation during the previous 3 weeks * Any metallic, electric, electronic or magnetic device or object not removable * Claustrophobia