A Trial of Treatment With Lenalidomide-Melphalan-Dexamethasone in Patients With Primary (AL) Amyloidosis

Inclusion Criteria: * Biopsy proven systemic untreated AL amyloidosis requiring systemic chemotherapy * Not eligible for or refused HDM * Measurable plasma cell disease * Life expectancy \> 3 months * WHO performance status \< 3 * NYHA \< stage IV * Understand and voluntarily sign an informed consent form * Laboratory test results within these ranges Absolute neutrophil count \> 1.5 x 109/L Platelet count \> 100 x 109/L Creatinine Clearance / MDRD \> 40 ml/min Total bilirubin \> 2,5 mg/dL * Females of childbearing potential (FCBP) must agree to use two reliable forms of contraception simultaneously or to practice complete abstinence from heterosexual intercourse during the following time periods related to this study: 1) for at least 28 days before starting study drug; 2) while participating in the study; and 3) for at least 28 days after discontinuation from the study. Exclusion Criteria: * Multiple Myeloma stage II and III (Durie and Salmon) * Previous organ transplantation * Not able to visit the Amyloid Clinic in Heidelberg once per month * Refusal of aspiration of 100 ml bone marrow at study inclusion * Any serious medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from signing the informed consent form. * Pregnant or breast feeding females. (Lactating females must agree not to breast feed while taking lenalidomide). * Any condition, including the presence of laboratory abnormalities, which places the subject at unacceptable risk if he/she were to participate in the study or confounds the ability to interpret data from the study. * Use of any other experimental drug or therapy within 28 days of baseline. * Known hypersensitivity to thalidomide. * The development of erythema nodosum if characterized by a desquamating rash while taking thalidomide or similar drugs. * Any prior use of lenalidomide. * Concurrent use of other anti-cancer agents or treatments. * Known positive for HIV or infectious hepatitis, B or C. * Patients who are in a depending position of the Sponsor or the Principal Investigator