Local Heat Therapy Versus Sodium Stibogluconate for the Treatment of Cutaneous Leishmaniasis

Inclusion Criteria: * Department of Defense (DOD) Healthcare beneficiary * Parasitologic diagnosis of cutaneous Leishmania infection (Inclusion criteria for randomization includes that must be Leishmania major species) * Willing to locate to WRAMC area during treatment and perform subsequent follow-up visits if needed (If not active duty on orders, then the participant will bear the cost of food and lodging during the initial 10-day outpatient treatment period at Walter Reed Army Medical Center) * Able to provide informed consent * All participants (both male and female) must agree to take precautions not to become pregnant or father a child for at least 2 months after receiving sodium stibogluconate Exclusion Criteria: * Unable to provide informed consent * Pregnancy (females of child bearing potential must have negative urine human chorionic gonadotropic hormone \[HCG\] within 48 hours of the start of infusion period) * History of hypersensitivity to pentavalent antimonials * Serious medical illness: 1. QTc interval \>/= 0.5 sec 2. severe cardiac disease 3. history of current pancreatitis 4. liver failure or active hepatitis with transaminases \>3X normal 5. renal failure or creatinine \>2.5 6. thrombocytopenia (platelets \<75,000) 7. white blood cell count \<2000 8. hematocrit \<25 9. absence of palpable extremity pulses in the limb requiring treatment * History of serious allergic reaction to local anesthetics * Location of lesion not amenable to local therapy (such as close to eye, mucous membranes, face, cartilage) * Presence of pacemaker and/or other implanted metallic devices * Breast feeding * Men unwilling to avoid fathering a child during and/or in the two months following receiving the treatment * Women unwilling to avoid pregnancy for at least two months after receiving the treatment * More than 20 lesions, or multiple lesions which in the opinion of the investigator would not be well treated with heat therapy