Ghrelin and Insulin Resistance

Vanderbilt University Medical Center20 enrolled

Overview

Ghrelin, a hormone produced in the stomach that stimulates hunger and food intake, declines immediately after weight loss surgery. Some studies suggest that ghrelin may worsen an individual's ability to respond to insulin. The purpose of this study is to determine if the decline in ghrelin levels after weight loss surgery contributes to the improvement of insulin sensitivity.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Obesity Insulin Resistance Normal Weight,Healthy Controls

Interventions

Ghrelin infusion to assess effects on insulin sensitivityDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria for RYGB group: * Age 18-65 * BMI \> 35 kg/m2 * Scheduled for bariatric surgery at Vanderbilt University Medical Center Inclusion Criteria for Lean group: * Age 18-65 * BMI \< 30kg/m2 Exclusion Criteria: * Prior bariatric surgery * Serum creatinine \> 1.5 mg/dl * Hepatic enzyme elevations \> 2x upper limits of normal * Current use of warfarin or clopidogrel * Intercurrent infections * Females with positive pregnancy test * Abnormal ECG

Locations (1)

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Outcomes

Primary Outcomes

Evaluate the effect of ghrelin on insulin resistance in obese subject, as well as subjects in the immediate post-RYGB period.

Time frame: 1 year

Data from ClinicalTrials.gov

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