Biomarkers in Predicting Neurotoxicity in Patients With Colorectal Cancer Receiving Oxaliplatin

Institut Cancerologie de l'Ouest206 enrolled

Overview

RATIONALE: Studying samples of blood in the laboratory from patients receiving oxaliplatin for cancer may help doctors learn more about changes that occur in DNA and identify biomarkers related to neurotoxicity. PURPOSE: This phase II trial is studying biomarkers in predicting neurotoxicity in patients with colorectal cancer receiving oxaliplatin.

OBJECTIVES: Primary * Correlate predictive genetic, proteomic, and/or neurotrophic markers with neurological manifestations related to the administration of oxaliplatin in patients with colorectal carcinoma. Secondary * Differentiate between risk factors predictive of acute and chronic neurotoxicity. * Establish a possible relationship between acute and chronic neurotoxicity. OUTLINE: This is a multicenter study. Patients receive oxaliplatin every 2 weeks as part of a FOLFOX chemotherapy regimen. Blood samples are collected 15 days prior to beginning chemotherapy, prior to each course of chemotherapy, and at 1 month after completion of chemotherapy for pharmacogenetic and laboratory biological studies. Patients with chronic neurotoxicity undergo additional blood sample collection at 3, 6, 9, and 12 months after completion of chemotherapy. Samples are analyzed for the detection of gene variants involved in the oxalate and fluorouracil metabolic pathway; neurotrophic factors; proteomic analysis of plasma proteins and peptides; and for biological testing of neurotoxicity.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Enrollment

206

Conditions

Chemotherapeutic Agent Toxicity Colorectal Cancer Neurotoxicity

Interventions

FOLFOX regimenDRUG

fluorouracilDRUG

leucovorin calciumDRUG

oxaliplatinDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Histologically confirmed colorectal cancer * Requires treatment with oxaliplatin (as part of a FOLFOX regimen) * No brain metastases or symptomatic meningitis PATIENT CHARACTERISTICS: * WHO performance status 0-2 * Life expectancy \> 3 months * ANC ≥ 1 x 10\^9/L * Platelet count ≥ 100 x 10\^9/L * Total bilirubin ≤ 2 times upper limit of normal (ULN) * Transaminases ≤ 3 times ULN * Alkaline phosphatase ≤ 5 times ULN * Not pregnant or nursing * Fertile patients must use effective contraception * No prior or concurrent clinical neuropathy (regardless of the etiology) * No dihydropyrimidine dehydrogenase deficiency * No psychiatric illness that would preclude comprehension of the study or of the informed consent * No other severe illness that may worsen during treatment, including unstable cardiac disease, myocardial infarction within the past 6 months, or active uncontrolled infection * No psychological, social, familial, or geographical reason that would preclude study follow-up * Other cancer within the past 5 years allowed provided treatment did not include platinum derivatives or taxanes PRIOR CONCURRENT THERAPY: * See Disease Characteristics * Prior chemotherapy allowed (except for platinum derivatives or taxanes)

Locations (1)

Centre Paul Papin

Angers, France

RECRUITING

Outcomes

Primary Outcomes

Correlation of genetic profiles and peptide, protein, and neurotrophic factors with neurological toxicity

Data from ClinicalTrials.gov

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