Pilot Study on the Effect of Adding Raltegravir +/- a Second Drug on HIV Levels in the Gut

Inclusion Criteria: 1. Age 18 to 65 years 2. Infection with HIV-1, as documented by a licensed ELISA and confirmed by a Western blot or HIV-1 RNA at any time prior to study entry 3. On ART for at least 12 months prior to study entry with a regimen that includes at least two NRTIs and either an NNRTI or PI 4. No change in ART for at least 3 months prior to study entry. 5. CD4+ T cell count of 200 or greater within 30 days prior to study entry. 6. HIV-1 RNA level consistently below the limit of detection of commercial ultrasensitive assays (\<50 copies/mL) for at least 6 months before study entry. 7. Women of reproductive potential (those who have not undergone surgical sterilization via hysterectomy, bilateral oophorectomy, or tubal ligation and who have had menses in the preceding 24 months) must have a negative urine or serum pregnancy test within 48 hours prior to study entry. 8. All subjects must agree not to participate in the process of conception (such as active attempts to impregnate or become pregnant, sperm or egg donation, in vitro fertilization) while receiving study drugs and for 6 weeks after stopping study drugs. If participating in sexual activity that could lead to pregnancy, the subject and/or partner should use at least two reliable methods of contraception, including oral contraceptive pills, an intrauterine device (IUD), condoms, and a diaphragm or cervical cap with spermicide. 9. Ability and willingness to provide informed consent. Exclusion Criteria: 1. Any condition that, in the opinion of the GI specialist, would either be a contraindication to endoscopy or would increase the risk from sedation, endoscopy, or mucosal biopsies. These conditions may include, but are not limited to: * Significant complication (such as perforation) from prior endoscopy * Known bleeding diathesis * Platelet count \< 100,000 per microliter * INR \> 1.6 * Current use of antiplatelet agents (aspirin, other NSAIDS, clopidogrel (Plavix), other antiplatelet agents) or anticoagulants (heparin, low molecular weight heparin, warfarin, lepirudin, or other anticoagulants) and inability to temporarily hold such medications for endoscopy. * Active angina, unstable angina, or MI within 2 months prior to study entry * Decompensated CHF * Respiratory insufficiency with FEV1 \< 1L, resting hemoglobin saturation of \<92%, or need for oxygen supplementation * OSA requiring CPAP * Ongoing substance abuse * Peripheral glucose \> 350 mg/dL 2. Prior use of raltegravir 3. Any condition that, in the opinion of the infectious disease (ID) specialist, would be a contraindication to raltegravir. These conditions may include, but are not limited to: unstable clinical condition (such as recent hospitalization, cancer with need for chemotherapy or radiation); severe hepatic insufficiency; need for contraindicated medicines; breastfeeding; or high risk for myopathy or rhabdomyolysis. 4. Calculated creatinine clearance (CrCl) \< 50 mL/min, as estimated by the Cockcroft-Gault equation 5. AST (SGOT), ALT (SGPT), alkaline phosphatase, or bilirubin \> 3x the upper limit of normal (ULN). 6. LDL \> 200 mg/dL or TG \> 400 mg/dL in fasting lipids, as measured within three months prior to screening or at the time of screening 7. Plan to change the background ART within 16 weeks after study entry 8. Receipt of any HIV vaccine 9. Receipt of a non-HIV vaccine within 30 days prior to study entry 10. An opportunistic infection within 60 days prior to study entry 11. Use of significant immunosuppressive medications (such as systemic corticosteroids, tacrolimus, sirolimus, mycophenolate, azathioprine, interferon, and cancer chemotherapy) within 60 days prior to study entry. 12. Active drug or alcohol abuse that, in the opinion of the investigator, would interfere with adherence to the requirements of the study