Effects of Fenofibrate on Metabolic and Reproductive Parameters in Polycystic Ovary Syndrome

Inclusion Criteria: * premenopausal women ≥ 18 years * diagnosis of PCOS based on the recent 2006 Androgen Excess Society criteria (modified from Rotterdam 2003) * waist circumference \>88 cm * fasting TG 2.0 - 5.0 mmol/L * stable on any type of oral contraceptive for a minimum of 3-months Exclusion Criteria: * known contraindications for MRI * pregnancy, lactation, desire to become pregnant * participation in another clinical trial * fasting TF level ≥ 5.0 mmol/L * AST or ALT \> 2.5 times upper limit of normal (ULN) * creatinine kinase (CK) \> 6x ULN * creatinine \> 115 μmol/L * fasting glucose ≥ 7.0 mmol/L and/or 2h glucose post oral glucose tolerance test (OGTT) ≥ 11.1 mmol/L or personal history of DM2 * personal history of renal disease, liver disease (except NAFLD), or heart disease * body mass index (BMI) \< 18 or \> 40 kg/m² * increased alcohol use (\>9 standard drinks per week \[standard drink = 12oz beer, 5oz wine, or 1.5oz spirits\]) or drug use * use of other hormonal contraception, growth hormone, glucocorticoids, anti-diabetic/anti-dyslipidemia medications, or anabolic steroids.