The objective of the Program of Rehabilitative Exercise and Education to avert Vascular Events after Non-disabling stroke and Transient ischemic attack (PREVENT) Trial is to determine whether the timely delivery of secondary stroke prevention strategies will reduce modifiable vascular risk factors in two groups of people who have survived NDS or TIA. One group will receive a comprehensive education and exercise program (PREVENT); the other group will receive usual care (USUAL CARE). We will measure modifiable vascular risk factors in both groups. We will also compare the effects of PREVENT vs USUAL CARE on exercise capacity, walking endurance, and daily physical activity. In addition, we will compare thinking ability, depression, achievement of personal goals for healthy behavior, and health-related goal attainment and health-related quality of life. Finally, we will compare outcomes in urban and rural settings as well as costs of the PREVENT program and USUAL CARE in order to assess sustainability of the PREVENT program.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE
Enrollment
187
12-week program of aerobic/strengthening exercises and education designed to induce physiological and behavioral changes deemed necessary to reduce vascular risk
Three or more out-patient visits to the neurovascular clinic for assessment, counseling and referral to appropriate health care professionals.
Halifax Infirmary Site, QEII Health Sciences Centre
Halifax, Nova Scotia, Canada
Annapolis Valley Regional Hospital
Kentville, Nova Scotia, Canada
systolic blood pressure (primary vascular risk factor being assessed)
Time frame: baseline, post-intervention, 6 months, 12 months
diastolic blood pressure
Time frame: baseline, post-intervention, 6 months, 12 months
waist circumference
Time frame: baseline, post-intervention, 6 months, 12 months
12-hour fasting lipid profile
Time frame: baseline, post-intervention, 6 months, 12 months
12-hour fasting glucose/hemoglobin A1C
Time frame: baseline, post-intervention, 6 months, 12 months
exercise capacity
Time frame: baseline, post-intervention, 12 months
daily physical activity
Time frame: baseline, post-intervention, 6 months, 12 months
walking endurance
Time frame: baseline, post-intervention, 6 months, 12 months
cigarette smoking
Time frame: baseline, post-intervention, 6 months, 12 months
medication adherence
Time frame: baseline, post-intervention, 6 months, 12 months
cognition
Time frame: baseline, 12 months
depression
Time frame: baseline, post-intervention, 6 months, 12 months
health-related quality of life
Time frame: baseline, post-intervention, 6 months, 12 months
health-related goal attainment
Time frame: baseline, post-intervention, 6 months, 12 months
direct health costs
Time frame: baseline, post-intervention, 6 months, 12 months
secondary vascular events
Time frame: baseline, post-intervention, 6 months, 12 months
daily step count
Time frame: baseline, post-intervention, 12 months
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