The regulation by DPP-4 inhibition after ingested of different individual macronutrients is not known. Therefore, this study examines the influence of ingestion of fat, protein, glucose or mixed meal on the concentrations of incretin hormones and insulin secretion with or without concomitant administration of a DPP-4 inhibitor (sitagliptin).
Meal ingestion releases gut hormones which stimulate insulin secretion. A most important gut hormone is the incretin hormone glucagon-like peptide-1 (GLP-1). GLP-1 is rapidly degraded and inactivated after its release by the enzyme dipeptidyl peptidase-4 (DPP-4). Inhibition of DPP-4 therefore increases the concentration of active GLP-1 after meal ingestion, which augments insulin secretion. How this process is regulated after ingested of different individual macronutrients is not known. Therefore, this study examines the influence of ingestion of fat, protein, glucose or mixed meal on the concentrations of incretin hormones and insulin secretion with or without concomitant administration of a DPP-4 inhibitor (sitagliptin).
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
12
100 mg sitagliptin before ingestion of macronutrient
A placebo tablet is given before ingestion of macronutrients
Department of Clinical Sciences Lund, Lund University
Lund, Sweden
Glucagon-like Peptide-1 Secretion After Meal Ingestion
Plasma GLP-1 levels will be measured during 300 min after meal ingestion for estimation of GLP-1 secretion
Time frame: 300 min
Insulin Secretion After Ingestion of Meal
Plasma insulin levels will be measured during 300 min after meal ingestion to estimation of insulin secretion
Time frame: 300 min
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