Benefit of Early Protocol Biopsy and Treatment of Subclinical Rejection

Inclusion Criteria: * Subject is the recipient of a first or second cadaveric or living donor mismatched (at least one mismatch) renal transplant * If female and of child-bearing potential, subject has a negative pregnancy test and utilizes adequate contraceptive methods Exclusion Criteria: * Recipients of a kidney from a donor over 65 years of age * Recipient of non-related donor kidney with peak pre-transplant PRA \> 50 * Subject has lost a previous graft to rejection less than one year from transplant * Subject who has received an investigational drug within three months prior to randomization * Subjects who are pregnant or breastfeeding * Subject receives a kidney lacking a pre-implantation biopsy * Subject has significant disease or disability (e.g. malignancy or uncontrolled infection) which prevents adherence to the protocol