A Study of Sunitinib in Recurrent and/or Metastatic Adenoid Cystic Carcinoma of the Salivary Glands

Inclusion Criteria: * Patients must have histologic or cytologic adenoid cystic carcinomas of major or minor salivary gland origin. * Patients must have recurrent and/or metastatic disease that is progressive and not amenable to surgery or curative radiotherapy occurring within 6 months of study entry: * at least a 20% increase in radiologically or clinically measurable disease; * appearance of any new lesions or * deterioration in clinical status * Patients must have measurable disease, at least one lesion that can be accurately measured in at least one dimension as \>20 mm with conventional techniques or as \>10 mm with spiral CT scan. * Patients with prior therapy with at least a 4 weeks' interval between any chemotherapy (6 weeks for nitrosoureas or mitomycin C), radiotherapy or surgery and study enrollment. Exceptions may be made for low dose, non-myelosuppressive radiotherapy. * Patients must be 18 years of age or older. * Life expectancy of greater than 12 weeks. * Patients must have normal organ and marrow function as defined below: * leukocytes \>3,000/μL * absolute neutrophil count \>1,500/μL * platelets \>100,000/μL * total bilirubin within normal institutional limits * AST(SGOT)/ALT(SGPT) ≤2.5 X institutional upper limit of normal * amylase/lipase within normal institutional limits * creatinine within normal institutional limits * creatinine clearance \>60 mL/min/1.73 m2 for patients with creatinine levels above institutional normal * Cardiac ejection fraction within the institutional range of normal as measured by ECHO or MUGA scan. * Patients must have QTc \< 500 msec on baseline ECG. * Patients with New York Heart Association (NYHA) Class II cardiac function: * with a history of Class II heart failure who are asymptomatic on treatment * with prior anthracycline exposure * who have received central thoracic radiation that included the heart in the radiotherapy port. * Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control or abstinence) prior to study entry and for the duration of study participation. * Ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria: * Patients who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier. At least 4 weeks must have elapsed since any major surgery. * Patients receiving any other investigational agents. * History of allergic reactions attributed to compounds of similar chemical or biologic composition to sunitinib. * Patients with QTc prolongation or other significant ECG abnormalities. * Patients with poorly controlled hypertension. * Patients who require use of therapeutic doses of coumarin-derivative anticoagulants such as warfarin, although doses of up to 2 mg daily are permitted for prophylaxis of thrombosis. Note: Low molecular weight heparin is permitted provided the patient's PT INR is \<1.5. * Patients with any condition that impairs their ability to swallow and retain sunitinib tablets. * Patients with any of the following conditions: * Serious or non-healing wound, ulcer, or bone fracture. * History of abdominal fistula, gastrointestinal perforation, or intraabdominal abscess within 28 days of treatment. * Any history of cerebrovascular accident or transient ischemic attack within 12 months prior to study entry. * History of myocardial infarction, cardiac arrhythmia, stable/unstable angina, symptomatic congestive heart failure, or coronary/peripheral artery bypass graft or stenting within 12 months prior to study entry. * History of pulmonary embolism within the past 12 months. * Class III or IV heart failure as defined by the NYHA. * Patients taking medications that are potent inducers or inhibitors of the CYP3A4 liver enzyme (unless deemed acceptable by the Principal Investigator). * Patients with a pre-existing thyroid abnormality who are unable to maintain thyroid function in the normal range with medication. * Patients with known brain metastases. * Patients with uncontrolled intercurrent illness including, ongoing or active infections or psychiatric illness/social situations that would limit compliance with study requirements. * Pregnant women. Breastfeeding should be discontinued if the mother is treated with sunitinib. * HIV-positive patients on combination antiretroviral therapy * Patients taking any of the medications that may cause QTc prolongation unless the required washout period has been met.