Fatty Liver and Ectopic Fat in Overweight and Obese Patients

Centre Hospitalier Universitaire de Nice56 enrolled

Overview

The aim of the study is to find new clinico-biological and medical imaging parameters associated with non alcoholic steatohepatitis in overweight and obese patients.

Non invasive assessment of liver fibrosis and liver inflammation and steatosis is clinically relevant in patients exposed to non alcoholic fatty liver diseases. The aim of the study is to find new clinico-biological and medical imaging parameters associated with non alcoholic steatohepatitis in overweight and obese patients. Fatty liver and ectopic fat accumulation will be particularly assessed.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Steatohepatitis

Interventions

liver biopsyPROCEDURE

liver biopsy

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * BMI between 25 and 40 * ALAT level superior to normal level even after 3 months of diet * alcohol consumption \< 20 g/j for women and \< 30 g/j for men Exclusion Criteria: * HIV, hepatitis B virus, hepatitis C virus positive * known hemochromatosis * glycemia \> 1.26 g/L or under anti-diabetic treatment

Locations (1)

Hepatogastroenterology, Hôpital l'Archet, CHU de Nice

Nice, France

Outcomes

Primary Outcomes

Liver status will be will be determined by liver biopsy, non invasive liver assessment. Biological and medical imaging parameters will be use to characterize our patients.

Time frame: at inclusion and at year 1

Secondary Outcomes

Non invasive liver assessment, biological and medical imaging parameters will be use to characterize our patients.

Time frame: at year 1

Data from ClinicalTrials.gov

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