Single Ascending Dose Study With Healthy Male Volunteers and Type II Diabetic Patients

Inclusion Criteria: * Part A,Healthy male subjects, aged between ≥20 and ≤40 years. * Part B,Male T2DM patients, aged between ≥20 and ≤65 years. Treatment with metformin as single therapy for T2DM for at least 30 days prior to enrollment Exclusion Criteria: * Part A,Clin sign illness or clin relevant trauma, as judged by the investigator, within 2 weeks before the first administration of the IP. * Part A Clin sign abnormalities in clinical chemistry, haematology, or urinalysis results as judged by the investigator * Part B, History of ischemic heart disease, symptomatic heart failure, stroke, transitory ischemic attack or symptomatic peripheral vascular disease. * Any clinically significant abnormality identified on physical examination, laboratory tests or ECG, which in the judgment of the investigator would compromise the patient's safety or successful participation.