Influence of Muscle Relaxation on a Closed-loop Anesthesia System

Hopital Foch140 enrolled

Overview

Total intra-venous anesthesia can be provided using a closed-loop system guided by the bispectral index. The purpose of this study is to determine if myorelaxation modifies its functioning.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

140

Conditions

Anesthesia, General

Interventions

muscle relaxantDRUG

muscle relaxant administration throughout anesthesia

normal salineDRUG

no muscle relaxant throughout anesthesia (normal saline infused as a placebo)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients scheduled for a surgical procedure which not require a myorelaxation Exclusion Criteria: * age less than 18 years, * ASA III and above, * pregnant woman * combined general and regional anesthesia, * history of prolonged myorelaxation due to a decrease in cholinesterase, * patient with a known lack in cholinesterase, * history of cerebral or psychiatric central, * allergy to latex, propofol, remifentanil, morphine, muscle relaxant or any of the excipients, * known hypersensitivity to remifentanil or to an other derivative of fentanyl, * presence of a pacemaker, * psychotropic or agonist-antagonist morphine treatment, * planned post-operative sedation.

Locations (3)

CHU Besançon

Besançon, France

Institut Paoli-Calmette

Marseille, France

Hôpital Foch

Suresnes, France