Different Dyskinesias in Parkinson's Disease and Their Relation to Levodopa Pharmacokinetics

Uppsala University5 enrolled

Overview

The purpose of this study is to study different kinds of dyskinesias in advanced Parkinson's disease appearing at different levels of levodopa infusion dose. The hypothesis is that different dyskinesias (dystonia, chorea) correlate to different levels of levodopa concentrations, as detected in plasma.

By using duodenal infusion of levodopa/carbidopa, the plasma concentration of levodopa can be kept fairly constant. Different doses, 10-20% higher or lower than the individually optimized dose will be used. Motor performance is captured by video recordings to be compared to/correlated with plasma levodopa concentrations.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Parkinson Disease Dyskinesias

Interventions

levodopa/carbidopaDRUG

intestinal gel, for continuous daytime infusion

Eligibility

Sex: ALLMin age: 30 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of idiopathic Parkinson's disease * Ongoing treatment with Duodopa * Occurrence of dyskinesias, difficult to manage * Age 30-90 years * Hoehn \& Yahr stage 3-5 at worst Exclusion Criteria: * Treatment with dopamine agonist or glutamate antagonist * Dementia * Psychosis * Treatment with typical neuroleptics

Locations (1)

Uppsala University Hospital

Uppsala, Sweden

Outcomes

Primary Outcomes

Correlation between plasma levodopa concentration and choreatic dyskinesia, dystonia, and parkinsonism

Time frame: 3 days

Secondary Outcomes

Correlation between choreatic dyskinesia, dystonia, and parkinsonism.

Time frame: 3 days

Data from ClinicalTrials.gov

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