Efficacy of Topotecan and Lapatinib in Early Recurrent Ovarian or Peritoneal Cancer

Inclusion Criteria: * Age superior or equal 18 years * primitive ovarian adenocarcinoma histologically confirmed * or peritoneal or fallopian tube adenocarcinoma histologically confirmed * Progression or relapse within 12 months after the end of first line of platin based chemotherapy * association in first line with other anticancer agent is allowed (taxanes, anthracyclines, alkylants or gemcitabine) and with an anti-angiogenic (bevacizumab, sunitinib). * intra-peritoneal chemotherapy in first line is possible * No previous treatment with HER inhibitors (ex : gefitinib) * HER status not necessary * measurable lesions (RECIST criteria). and/or CA125 value higher than 2 fold the normal value or CA125 higher than 2 fold nadir value (if no normalized) proved by two samples distant of 1 month * OMS inferior or equal 2. * biological parameters as follow: creatininemia ≤ 150 µmol/L or clearance ≥ 50 mL/min,bilirubin ≤ 1,5 LNS,transaminases and or alcalin phosphatases ≤ 2 LNS without hepatic metastasis or ≤ 3 LNS if hepatic metastasis,neutrophils ≥ 1,5.109/L,plaquettes ≥ 100.109/L. * normal FEV * No previous treatment by chemotherapy, hormonotherapy, immunotherapy or radiotherapy within 4 weeks before inclusion * No concomitant treatment forbidden with lapatinib. * No previous treatment by Amiodarone in 6 months before inclusion * signed informed consent Exclusion Criteria: * Previous treatment with : * intensive chemotherapy with autograft * two lignes of chemotherapy * previous total abdominal irradiation * previous chemotherapy with anti-HER treatment * History of brain or meningitis metastasis uncontrolled. * Malignancies except for adequately treated carcinoma in situ of the cervix and/or basal cell skin cancer. * uncontrolled infectious pathology * uncontrolled cardiovascular disease * Patients with an active intestinal occlusion not permit oral treatment * known hypersensibility to topotecan and its excipients * Woman of childbearing potential who are unwilling or unable to use an acceptable method to avoid pregnancy for the entire study period * Individual deprived of liberty