Safety and Efficacy Study of RT001 to Treat Moderate to Severe Lateral Canthal Lines

Inclusion Criteria: * Female or male; 30 to 55 years of age * Bilateral lateral canthal lines rated as moderate or advanced * Willing to refrain from receiving facial fillers, laser treatments, use of any product that affects remodeling or a product that may cause an active dermal response in the treatment area beginning at Screening through End of Study * Women of childbearing potential must be practicing and willing to continue to use an effective method of birth control during the course of the study Exclusion Criteria: * Muscle weakness or paralysis in the area receiving study treatment * Active skin disease or irritation at the treatment areas * Undergone any procedures that may affect the lateral canthal region during the past 12 months prior to Screening * Previous treatment with botulinum toxin (any serotype) in the head or neck area within 9 months prior to Baseline (Day 0) * Use of a topical steroid on either of the treatment areas or use of medications that suppress the immune system 30 days prior to Screening and continuing through End of Study (Day 28) * Any abnormality on the electrocardiogram (ECG) at Screening or any history of clinically significant arrhythmia, unstable angina, myocardial infarction or congestive heart failure