Protocol to Obtain Blood Samples for Leukemia Research

N/ACompletedNCT00889031

Dartmouth-Hitchcock Medical Center187 enrolled

Overview

The purpose of this study is to collect a blood sample in patients with Chronic Lymphocytic Leukemia (CLL).

The blood sample will be used in the laboratory to perform studies focusing on Chronic Lymphocytic Leukemia (CLL).

Study Type

OBSERVATIONAL

Enrollment

187

Conditions

Chronic Lymphocytic Leukemia

Interventions

No InterventionOTHER

Patients with Chronic Lymphocytic Leukemia (CLL)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing routine blood draws as part of their ongoing follow-up for Chronic Lymphocytic Leukemia (CLL) at the Norris Cotton Cancer Center of DHMC. Exclusion Criteria: * Patients who have received cytotoxic drug, oral or intravenous steroid or targeted antibody therapy for CLL or other disease process within the past 6 months are excluded. Use of intravenous immunoglobulin (IVIg) is not a reason for exclusion.

Locations (1)

Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, United States

Outcomes

Primary Outcomes

To determine the frequency with which CLL cells incubated ex vivo with vincristine undergo rapid interphase apoptosis.

Time frame: 2 Years

Secondary Outcomes

To determine whether suppression or inhibition of BCL2 family members can acutely sensitize CLL cells to vincristine.

Time frame: 2 Years

Data from ClinicalTrials.gov

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