The objective is to, among obese adolescents, study impact of regular physical activity or metformin therapy on nocturnal blood pressure and related cardiovascular disease risk factors.
Forty subjects will be assigned to the exercise intervention group, thirty to the metformin therapy group and thirty to the control group. Group I will be treated daily with metformin. Group II will perform exercise (endurance) three times/week with a personal coach and group III will serve as control. All participants will be examined at baseline, after 3 months of intervention, after 6 months of intervention and after one year of intervention. Examination includes anthropometric measures, measures of ambulatory 24-h blood pressure and insulin sensitivity, measures for function and structure of the heart and vessels, analysis of atherogenic factors in the blood, aerobic fitness testing and measurement of daily physical activity.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
26
2000 mg/day for one year
3 times/week with a personal coach for one year. Endurance training.
Karolinska Institutet, Karolinska University Hospital Huddinge
Stockholm, Sweden
Normalization of nocturnal blood pressure dipping
Time frame: Before and 3, 6 and 12 months of intervention
Normalization of insulin metabolism and cardiovascular structure and function
Time frame: Before and 3, 6 and 12 months of intervention
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