Pancreaticobiliary reflux has been found in patients with cholelithiasis and gallbladder cancer associated with normal pancreaticobiliary union. However, the presence of pancreaticobiliary reflux has not been studied in patients without gallstones (healthy gallbladders). The authors believe that pancreaticobiliary reflux might be a normal phenomenon in patients with and without gallstones, although in patients with cholelithiasis it might constitute a pathological condition associated with dismotility of the biliary tree and the sphincter of Oddi.
The objective of this study is to measure the levels of amylase and lipase in gallbladder bile of patients without gallstones and compare these values to the values of amylase and lipase of patients with gallstones and normal pancreaticobiliary union evidenced by intraoperative cholangiography.
Study Type
OBSERVATIONAL
Enrollment
197
Interventions were exactly similar for both groups, and that is how it was intended to be: Gallbladder bile sampling: Sample 5 cc of gallbladder bile after the cystic duct has been clipped or ligated. Intraoperative cholangiography: Perform cholangiography before the cholecystectomy is finished
Hospital de La Serena
La Serena, Coquimbo Region, Chile
Amylase and Lipase Values in Gallbladder Bile
Normal values of lipase and amylase in gallbladder bile should be zero
Time frame: 24 hours
Amylase and Lipase Values in Normal Gallbladders
Time frame: 24 hours
Amylase and Lipase Values in Gallbladders With Cholelithiasis
Time frame: 24 hours
Normal Operative Cholangiography
Time frame: 24 hours
Normal Preoperative Serum Values of Amylase and Lipase
Time frame: 24 hours
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