Study of Pain Control in Hemorrhoidectomy

Inclusion Criteria: * Age \> 18 years of age at the Screening visit * American Society of Anesthesiologists (ASA) class 1-3 * Scheduled to have a two or three column excisional hemorrhoidectomy under general anesthesia using the Milligan-Morgan technique * For female subjects, surgically sterile or at least two years menopausal, or using an acceptable method of birth control; must have a documented negative blood or urine pregnancy test within 24 hours before surgery * Clinical lab values less than or equal to twice the upper limit of normal or, if abnormal, deemed not clinically significant per the Investigator. * Ability to understand the requirements of the study, provide written informed consent, abide by the study restrictions, and agree to return for the required assessments * Able to speak, read, and understand the language of all subject-facing documents, including the ICF and study questionnaires * Able and willing to comply with all study visits and procedures Exclusion Criteria: * Single-column hemorrhoidectomy or hemorrhoidectomy without an internal component * Body weight less than 50 kilograms (110 pounds) * History of hypersensitivity or idiosyncratic reactions or amide-type local anesthetics, opioids, or propofol * Current painful physical condition or concurrent surgery other than hemorrhoids that may require analgesic treatment (such as non-steroidal anti-inflammatory drug \[NSAID\], opioid, selective serotonin reuptake inhibitor \[SSRI\], tricyclic antidepressant, gabapentin, pregabalin) in the postoperative period for pain that is not strictly related to the hemorrhoidectomy procedure and may confound the postoperative assessments * Concurrent fissurectomy * Use of any NSAID including selective COX-2 inhibitor, opioid, SSRI, tricyclic antidepressant, gabapentin, or pregabalin within three days of surgery * Use of acetaminophen within 24 hours of surgery * Chronic users of analgesic medications, including taking opioid medications for more than 14 days in the last 3 months, or non-opioid pain medications more than 5 times per week * History of, suspected, or known addiction to or abuse of drugs or alcohol within the past two years * Current use of glucocorticosteroids or use of glucocorticoids within one month of enrollment into this study * HIV infection or hepatitis * Currently pregnant, nursing, or planning to become pregnant during the course of the study or within one month of study drug administration * Any psychiatric, psychological, medical, or laboratory condition that the investigator feels makes the subject an inappropriate candidate for this clinical trial * Subjects who have received another investigational drug within the longer of the last 30 days or 10 elimination half-lives * Previous participation in a SKY0402 study * Failure to pass drug and alcohol screen