Efficacy of Intramuscular Naloxone 0.4mg. in Prophylaxis of Intrathecal Morphine Induced Pruritus After Cesarean Section

Mahidol University60 enrolled

Overview

The purpose of this study is to determine whether intramuscular naloxone 0.4mg. is effective in prophylaxis of intrathecal morphine induced pruritus after cesarean section.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Morphine Adverse Reaction

Interventions

naloxoneDRUG

naloxone 0.4mg.(1 ml) intramuscular

normal salineDRUG

normal saline 1 ml IM

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patient schedule for cesarean section ASA class 1 Exclusion Criteria: * have contraindication for spinal block * complicated pregnancy * have history of drug abuse during pregnancy * obesity BMI\>35kg./m2

Locations (1)

Anesthesiology department, Siriraj Hospital, Mahidol University

Bangkok, Thailand

Outcomes

Primary Outcomes

efficacy of intrathecal naloxone 0.4mg. in prophylaxis of intrathecal morphine induced pruritus after cesarean section

Time frame: 24 hour

Data from ClinicalTrials.gov

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