Omega-3 Fatty Acids in Bipolar Patients With a Low Omega-3 Index and Reduced Heart Rate Variability

Inclusion Criteria: 1. Subjects must meet the DSM-IV criteria for bipolar disorders, in remission 2. Age: 18 - 65 years 3. Low omega-3 index (\<5%) 4. SDNN \< 60 msec 5. Subjects must have adequate fluency in German or English to complete baseline and follow-up interviews and fill out the Beck Depression Inventory 6. Stable psychotropic medication for at least 2 weeks 7. Subjects must be able to give written informed consent Exclusion Criteria: 1. Subjects for whom the intake of omega-3 fatty acids is indicated according to recent treatment guidelines 2. Patients on Warfarin 3. Subjects with any acute and life-threatening condition, such as collapse and shock, acute myocardial infarction, stroke, embolism 4. Subjects with significant medical comorbidity 5. Pregnant subjects - due to any possible teratogenic effects of EPAX 6015 TG and corn oil, respectively, on the fetus - and breastfeeding subjects. In addition, women of childbearing potential who will not practice a medically accepted method of contraception will be excluded 6. Subjects who, in the investigator's judgement, pose a current significant suicidal or homicidal risk or patients who will not likely be able to comply with the study protocol 7. Subjects fulfilling the DSM-IV diagnostic criteria for current substance abuse