Liq-NOL Efficacy in Pediatric Patients With Down Syndrome

Inclusion Criteria: * Patients ranging from 6.0 years to 16 years of age. * Patients will have proven Trisomy 21. * Females, incapable of bearing children or capable of practicing adequate birth control methods. Abstinence will be acceptable. * Written informed consent will be obtained from parents of all subjects prior to enrollment. Verbal assent will be obtained from all patients with DS who have sufficient decision making ability and are at least 11 years old. Exclusion Criteria: * Patients who have insufficient mental and/or motor capacity to complete testing measures. * Patients less than 6 years or older than 16 years of age. * Patients receiving CoQ supplementation within one month prior to the study. * Patients with evidence of disease which may adversely affect CoQ absorption, e.g. chronic diarrhea or inflammatory bowel disease. * Patients participating in other research studies or having exposure to investigational drugs within one month prior to this study. * Females, capable of bearing children, who are unsure of their pregnancy status or not practicing adequate birth control methods. * Females who are pregnant. * Patients with a known allergy to CoQ. * Patients receiving drug treatment which is know to affect CoQ, e.g. cholesterol-lowering drugs such as "statins".