The Effect of Supplemental Docosahexaenoic Acid (DHA) on Neurocognitive Outcomes in Teen and Adult Women With Phenylketonuria(PKU)

Emory University33 enrolled

Overview

The purpose of this study is to determine if taking supplemental DHA improves measures of processing speed and executive function in teen and adult women with PKU.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Phenylketonuria

Interventions

Docosahexaenoic AcidDIETARY_SUPPLEMENT

Capsules providing 10 mg DHA/kg body weight/day taken once daily

Corn/soy oilDIETARY_SUPPLEMENT

Capsules taken once daily

Eligibility

Sex: FEMALEMin age: 12 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Females * Phenylketonuria * Ages 12 years and older * Able to complete neuropsychological testing Exclusion Criteria: * Pregnancy * Currently taking DHA supplement

Locations (1)

Emory University

Atlanta, Georgia, United States

Outcomes

Primary Outcomes

Cognitive processing speed

Time frame: 0 months, 4.5 months

Executive function

Time frame: 0 months, 4.5 months

Secondary Outcomes

Plasma and red blood cell DHA concentrations

Time frame: 0 months, 4.5 months

Data from ClinicalTrials.gov

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